Radar / AI models / NVIDIA RFD4-Proteina

NVIDIA RFD4-Proteina: open protein-design BioNeMo model

Open protein-design model from NVIDIA and the Baker Lab at UW Medicine's Institute for Protein Design, announced at GTC Berlin Oct 21. Generates protein sequences and 3D structures for protein binding, small-molecule binding, enzyme scaffolding and DNA binding. Available on build.nvidia.com, as a NIM microservice, on GitHub, Hugging Face and through Google Cloud and OpenAI partner endpoints.

new launchmodels · frontierJEV traction 0.7added 2026-10-21
Open NVIDIA RFD4-Proteina →View on the radar

Why it matters

First openly available protein-design model built with the Baker Lab's Institute for Protein Design: researchers can generate and agent-evaluate candidate designs against molecular constraints before lab testing, at about 13x the speed of RFdiffusion3 on 200-amino-acid proteins.

What you could build with it

A biotech startup screening enzyme candidates could wrap RFD4-Proteina's agent-accessible design loop with its own assay data, generating and ranking candidate binders in silico before committing to expensive wet-lab validation.

Does it hold up?

Too early to judge — released Oct 21; the only numbers so far are NVIDIA's own (leading across 10+ protein design tasks, 13x faster than RFdiffusion3 on 200-aa proteins). No independent wet-lab validation yet.

Built with NVIDIA RFD4-Proteina

Learn more

technical coverage of the GTC Berlin release (Unite.AI) →

First spotted on article: source.

More AI models

OpenAI publishes 722 AI-generated math manuscripts from an unreleased modelOpenAI released 722 mathematical manuscripts in 372 result families to GitHub under Apache-2.0, produced by an…models · JEV 0.74Tencent Hunyuan Hy3: open 295B MoE with 21B active under Apache 2.0Tencent open-sourced Hy3, a 295B-parameter mixture-of-experts model with only 21B parameters active per token, under…models · JEV 0.73NVIDIA Isaac Lab 3.0 GA + Isaac OS open runtime + Agile ONE SN humanoidMajor Isaac platform expansion at GTC Berlin Oct 21: Isaac Lab 3.0 is generally available as the open-source robot…models · JEV 0.73StepFun Step-5-Preview — open BF16 weights releasedStepFun published the full BF16 weights for its flagship Step-5-Preview agentic model (600B-parameter sparse MoE, 27B…models · JEV 0.73NVIDIA Nemotron 3.5 Retriever collection: Embed 8B/1B, Rerank 8B, Parse 631MNVIDIA's Oct 21 collection drop for agentic retrieval: Nemotron-3.5-Embed in 8B BF16, 1B BF16 and 1B NVFP4…models · JEV 0.72Kimi K3.1 Pro: Moonshot's 2.8T open-weight flagship officially launchesMoonshot AI officially launched Kimi K3.1 Pro on Oct 23, a mixture-of-experts model with 2.8 trillion total / 104…models · JEV 0.72

Get the week's best AI launches, plus 3 ideas worth building

One email every Saturday. Ranked by traction, not hype. Free.